Client Side Cache or CSC is just another term for the Offline Files feature in Windows operating systems. It’s most widely known as offline files only. But the cache location is named CSC. And this can be located in C:WindowsCSC.
We can disable Client Side Cache using the in-build graphical user interface(GUI) or through registry hacks also. Both UI and registry methods are different in Windows 2000/XP/Server 2003 and Vista/Windows 7.
Based on your OS edition you can refer one of the below articles to disable Client Side Cache.
Disable Offline Files or Client Side Cache in Windows XP
Disable Offline Files or Client Side Cache in Windows Vista
Disable Offline Files or Client Side Cache in Windows 7.
If you want to disable Client Side Cache with registry hacks then please read How to disable offline files using registry keys
If you want to disable Client Side Cache for a domain then refer How to disable offline files for all domain users